Tesamorelin — a synthetic GHRH analog — studied in growth-hormone signaling and metabolic research models.
Tesamorelin is a lab-made version of a natural hormone your body already produces called growth-hormone-releasing hormone (GHRH). Your brain normally releases GHRH to tell your pituitary gland to make growth hormone. The problem with giving the natural version as a drug is that the body breaks it down within minutes — an enzyme called DPP-IV chops it apart almost immediately. Tesamorelin is a slightly modified version that's resistant to that enzyme, so it lasts long enough to actually do its job (roughly 26–38 minutes in the body after injection). That modification — a small chemical group attached to one end — is the engineering insight that turned a useless-as-a-drug molecule into an FDA-approved medicine. The brand names are Egrifta (approved 2010) and Egrifta WR (approved March 2025, same drug in a more convenient format that needs mixing only once a week instead of daily). It was developed by a Canadian company called Theratechnologies.
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FDA-approved. Tesamorelin acetate was approved November 10, 2010 as Egrifta for the reduction of excess abdominal fat in HIV-infected adults with lipodystrophy (NDA 022505). A supplemental BLA for Egrifta WR (the F8 weekly-reconstitution formulation) was approved March 2025, maintaining bioequivalence while cutting injection volume by more than half. Tesamorelin remains the only FDA-approved member of the GHRH-analog class.
Tesamorelin is a 44-amino-acid GHRH(1-44) analog with an N-terminal trans-3-hexenoyl modification. PubChem indexes it at CID 16137828 with formula C221H366N72O67S and approximate molecular weight 5136 g/mol.
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