NA Semax — an acetylated Semax research peptide — based on the ACTH(4-7) fragment with a Pro-Gly-Pro stability extension.
Semax is a synthetic 7-amino-acid peptide developed in the 1980s at a Russian research institute. It was designed by taking a small piece of ACTH — a hormone your pituitary gland makes to trigger cortisol release — and modifying it. Scientists cut it down to a 4-amino-acid fragment (ACTH(4-7)) and added 3 more amino acids (Pro-Gly-Pro) at one end. That addition does two important things: it makes the peptide much harder for the body to break down, and it removes the cortisol-triggering effect entirely. The result is a peptide that may affect the brain without causing the stress hormone side effects of ACTH itself. It's taken as a nasal spray — a 0.1% solution of drops. You can't take it as a pill because it would be digested before it could work. Despite decades of study, no specific "receiver" on brain cells that Semax attaches to has ever been identified, even though its biological effects are well described in animal studies.
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Not FDA-approved for human use in the United States. No FDA IND is on file, and no Phase 2 or Phase 3 trial has ever been registered on ClinicalTrials.gov. Sold domestically only as a research chemical.
NA Semax is an acetylated/amidated Semax-family heptapeptide. The parent Semax reference sequence is MEHFPGP and PubChem indexes Semax at CID 9811102 with formula C37H51N9O10S and molecular weight 813.9 g/mol.
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